Sterilization of Bone Allografts
نویسندگان
چکیده
منابع مشابه
Effect of Chemical Sterilization on the Mechanical Properties of Human Cortical Bone Allografts
Introduction Musculoskeletal allografts are increasingly being utilized in a variety of orthopedic procedures. However, they pose the serious risk of viral or bacterial disease transmission as highlighted by the 2001 death of a young man from Clostridium sordellii sepsis after receiving a contaminated allograft. Gamma irradiation has been widely used to minimize this risk, but has been shown to...
متن کاملValidation of 11 kGy as a radiation sterilization dose for frozen bone allografts.
A radiation sterilization dose (RSD) of 25 kGy is deleterious to bone allografts. This study aimed to establish a lower RSD for bone allografts using method 1 of International Standard Organisation 11137.2:2006. This provides a database to select an RSD corresponding to an allograft's bioburden, given that the bioburden's gamma resistance is equal to or less than the standard. This can be verif...
متن کاملReducing the radiation sterilization dose improves mechanical and biological quality while retaining sterility assurance levels of bone allografts.
BACKGROUND Bone allografts carry a risk of infection, so terminal sterilization by gamma irradiation at 25kGy is recommended; but is deleterious to bone quality. Contemporary bone banking significantly reduces initial allograft bioburden, questioning the need to sterilize at 25kGy. METHODS We inoculated allograft bone with Staphylococcus epidermidis and Bacillus pumilus, then exposed them to ...
متن کاملHistological features of large bone allografts.
We performed biopsies during reoperation for minor complications in two active young patients 9 and 19 months after massive bone allograft implantation for bone tumour. The grafts were dead and resorption-apposition activity, when present, was predominantly in subperiosteal areas. Inflammatory infiltration was very seldom found. Features considered as 'microfractures' or 'microcracks' were note...
متن کاملPeculiar Immunobiology of Bone Marrow Allografts
Mice are capable of rejecting H-2-incompatible bone marrow grafts after a single lethal exposure to X-rays. The onset of rejection begins 18-24 hr after transplantation and is completed by 96 hr. Maturation of this type of allograft reactivity does not occur until the 22nd day of life. In adult mice, the resistance to marrow allografts can be weakened by administration of cyclophosphamide or de...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Infection Control & Hospital Epidemiology
سال: 2000
ISSN: 0899-823X,1559-6834
DOI: 10.1017/s0195941700043319